| Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 19778613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been extensively reported that diabetes mellitus (DM) patients have a higher risk of developing Alzheimer's disease (AD), but a mechanistic connection between both pathologies has not been provided so far. Carbohydrate-derived advanced glycation endproducts (AGEs) have been implicated in the chronic complications of DM and have been reported to play an important role in the pathogenesis of AD. The earliest histopathological manifestation of AD is the apparition of extracellular aggregates of the amyloid beta peptide (Abeta). To investigate possible correlations between AGEs and Abeta aggregates with both pathologies, we have performed an immuhistochemical study in human post-mortem samples of AD, AD with diabetes (ADD), diabetic and nondemented controls. ADD brains showed increased number of Abeta dense plaques and receptor for AGEs (RAGE)-positive and Tau-positive cells, higher AGEs levels and major microglial activation, compared to AD brain. Our results indicate that ADD patients present a significant increase of cell damage through a RAGE-dependent mechanism, suggesting that AGEs may promote the generation of an oxidative stress vicious cycle, which can explain the severe progression of patients with both pathologies. |
| | |
Authors:
|
Tony Valente; Alejandro Gella; Xavier Fern?ndez-Busquets; Mercedes Unzeta; Nuria Durany |
Related Documents
:
|
9574633 - Biology of neurological recovery and functional restoration after spinal cord injury. 9572283 - 3-hydroxybutyrate aids the recovery of the energy state from aglycaemic hypoxia of adul... 18594063 - Insulin resistance and hyperinsulinemia: you can't have one without the other. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-22 |
Journal Detail:
|
Title: Neurobiology of disease Volume: 37 ISSN: 1095-953X ISO Abbreviation: Neurobiol. Dis. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-11-25 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 67-76 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Molecular Biology, School of Medicine, Neuroscience Institute, Autonomous University of Barcelona, Bellaterra-08193, Barcelona, Spain. tonyvalente@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Alzheimer Disease / metabolism*, pathology Amyloid beta-Protein / metabolism* Brain / metabolism*, pathology Cell Count Diabetes Mellitus / metabolism*, pathology Female Fluorescent Antibody Technique Glycosylation End Products, Advanced / metabolism* Humans Immunohistochemistry Male Microglia / metabolism, pathology Middle Aged Peptide Fragments / metabolism* Plant Lectins Receptors, Immunologic / metabolism Senile Plaques / metabolism, pathology Thiazoles tau Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Amyloid beta-Protein; 0/Glycosylation End Products, Advanced; 0/MAPT protein, human; 0/Peptide Fragments; 0/Plant Lectins; 0/Receptors, Immunologic; 0/Thiazoles; 0/advanced glycosylation end-product receptor; 0/amyloid beta-protein (1-40); 0/tau Proteins; 0/tomato lectin; 2390-54-7/thioflavin T |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antioxidant effects of mycophenolate mofetil in a murine pleurisy model.
Next Document: CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice.