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Immunohistochemical analysis of hepatocyte growth factor and c-Met in plasma cell disease.
MedLine Citation:
PMID:  22276607     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Wader K F, Fagerli U-M, Børset M, Lydersen S, Hov H, Sundan A, Bofin A & Waage A (2012) Histopathology60,443-451 Immunohistochemical analysis of hepatocyte growth factor and c-Met in plasma cell disease Aims:  Interaction with the bone marrow microenvironment is important for homing and survival of myeloma cells. One cytokine involved in this process is hepatocyte growth factor (HGF). HGF, by binding to the receptor tyrosine kinase c-Met, mediates a broad range of tumour progression activities. Our aims were to investigate whether HGF and c-Met are present in bone marrow and extramedullary tumours from patients with monoclonal plasma cell disease, and whether c-Met is activated. Methods and results:  Expression of HGF, c-Met and phospho-c-Met was studied by immunohistochemistry in biopsies from 80 patients with monoclonal plasma cell disease. Cytoplasmic staining for HGF in plasma cells was demonstrated in 58 of 68 biopsies from multiple myeloma patients (85%), but also in biopsies from nine of 10 healthy individuals. Membranous staining for c-Met was found in 25 of 63 multiple myeloma patients (40%) and in none of 10 healthy individuals. Membranous staining for phospho-c-Met was found in biopsies from 15 of 21 c-Met-positive myeloma patients (71%). Conclusions:  Our data point to c-Met expression as one of the factors that distinguishes normal from malignant plasma cells, and indicate that the HGF/c-Met system is activated in multiple myeloma patients.
Authors:
Karin F Wader; Unn-Merete Fagerli; Magne Børset; Stian Lydersen; Håkon Hov; Anders Sundan; Anna Bofin; Anders Waage
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Histopathology     Volume:  60     ISSN:  1365-2559     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-1-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  443-451     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Limited.
Affiliation:
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim Department of Oncology, St Olav's Hospital, Trondheim Department of Immunology and Transfusion Medicine, St Olav's Hospital, Trondheim Department of Pathology, St Olav's Hospital, Trondheim Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, NTNU, Trondheim Department of Hematology, St Olav's Hospital, Trondheim, Norway.
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