| Immunohistochemical analysis of the expression of the c-myc oncoprotein in human stomach cancers. | |
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MedLine Citation:
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PMID: 1812039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an immunohistopathological study, we have used the specific monoclonal antibody myc 1-9E10 to the c-myc oncoprotein in 88 gastric carcinomas (22 gastric biopsies and 66 gastrectomies for cancer). Positive myc p62 immunoreactivity was shown in 48 (55%) cases with moderate or intense staining. The remaining 40 cases exhibited negative or equivocal staining. Normal stomach mucosa was generally nonreactive, with the exception of parietal cells. Elevated c-myc expression was not found to correlate with histological differentiation or in patients with metastases in one or more perigastric lymph nodes. A correlation was found between the level of c-myc expression and the stage of the disease, (p = 0.04); positive c-myc staining was found in 0/4 early gastric cancers and in 48/84 with advanced disease. Also, an association was found between the elevated c-myc expression and depth of invasion (p = 0.1; 0/4 mucosa and submucosa, 2/6 muscularis propria and 25/47 serosa). The c-myc monoclonal myc 1-9E10 may therefore be of use as a marker of advanced disease and depth of invasion in stomach cancer. |
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Authors:
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D A Spandidos; M Karayiannis; M Yiagnisis; K Papadimitriou; J K Field |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestion Volume: 50 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1991 |
Date Detail:
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Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 127-34 Citation Subset: IM |
Affiliation:
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Institute of Biological Research and Biotechnology, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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genetics*,
pathology Gastric Mucosa / pathology Gene Expression / genetics* Humans Immunoenzyme Techniques Lymphatic Metastasis Neoplasm Invasiveness Neoplasm Staging Proto-Oncogene Proteins c-myc / genetics* Stomach / pathology Stomach Neoplasms / genetics*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-myc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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