Document Detail

Immunohistochemical analysis of collagen expression in human corpora lutea during the menstrual cycle and early pregnancy.
MedLine Citation:
PMID:  16616079     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the characteristic structure and function of human corpora lutea (CL), various types of collagen expression were determined in the CL tissues during the menstrual cycle and early pregnancy. DESIGN: In vitro experiment. SETTING: Department of obstetrics and gynecology at a medical university. PATIENT(S): Regulatory cycling women and pregnant women with ovarian tumor and ectopic pregnancy who underwent adnexectomy. INTERVENTION(S): Immunohistochemistry for human type I, III, and IV collagen with specific monoclonal antibodies was used for analysis. MAIN OUTCOME MEASURE(S): Expression of type I, III, and IV collagen. RESULT(S): Immunohistochemical staining for type I and III collagen revealed intense staining of the CL stroma during early pregnancy, as compared with those in the menstrual cycle. Moreover, pericellular intense immunostaining for type IV collagen was observed around the luteal cells, especially luteal granulosa cells, of early pregnancy. CONCLUSION(S): These results suggest that alterations in distribution of collagen might play an important role in determining the physiology and structure of the CL during the menstrual cycle and early pregnancy.
Masaaki Iwahashi; Yasuteru Muragaki; Akira Ooshima; Naohiko Umesaki
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  85 Suppl 1     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, Japan.
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MeSH Terms
Collagen / metabolism*
Corpus Luteum / metabolism*
Gene Expression Regulation / physiology
Menstrual Cycle / metabolism*
Middle Aged
Pregnancy / metabolism*
Tissue Distribution
Reg. No./Substance:

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