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Immunohistochemical analysis of aquaporins in the fetal and adult vocal fold.
MedLine Citation:
PMID:  21225793     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study is to identify and compare the presence and location of aquaporins in the fetal and adult larynx using immunohistochemical techniques.
METHODS: Immunohistochemical staining was performed on adult and fetal true vocal fold specimens. The presence and location of aquaporins -1, -2 and -3 in the fetal specimens were then compared to the adult specimens.
RESULTS: Immunohistochemical analysis revealed a homogenous distribution of aquaporin -3 in the cell cytoplasm of adult lamina propria with a higher concentration in the superficial layer. Aquaporins -1 and -2 were not identified in either the adult specimens. No evidence of aquaporins were identified in the fetal lamina propria.
CONCLUSION: Aquaporin -3 was found in the lamina propria of adult true vocal cord specimens with a higher concentration in the superficial layer. No evidence of Aquaporins -1, -2, or -3 was found in fetal specimens.
Authors:
Michael A Goodier; Aimee P Goodier; Alexandra S Brown; John Schweinfurth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  120 Suppl 4     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S195     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology and Communicative Sciences, Department of Pathology, University of Mississippi Medical Center, USA.
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