| Immunohistochemical analysis of CD1a-labeled Langerhans cells in human dental periapical inflammatory lesions--correlation with inflammatory cells and epithelial cells. | |
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MedLine Citation:
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PMID: 11834096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Distribution and density of CD1a-labeled Langerhans cells (LCs) were examined in human dental periapical inflammatory lesions, and compared with inflammatory cell infiltration or epithelial cell proliferation. MATERIALS AND METHODS: Eighty three periapical lesions (26 apical granulomas (AGs), 8 epitheliated granulomas (EGs), 34 radicular cysts (RCs), 15 residual radicular cysts (RRCs)) were collected. As control, specimens of periodontal ligaments including Malassez epithelial rests were curetted from 21 teeth. LC densities were measured and various degrees of inflammatory cell infiltration were examined immunohistochemically. Labeling indices for the cellular proliferation markers Ki-67 antigen and DNA topoisomerase II alpha were calculated in the epithelial components. RESULTS: LCs were found in all periapical lesions but not in Malassez epithelial rests. LCs were more abundant in epithelial components than in subepithelial layers. Intraepithelial LCs were more frequent in RCs than in RRCs, whereas subepithelial LCs were less frequent in RRCs than in AGs and EGs. T lymphocytes consistently outnumbered macrophages, plasma cells and B lymphocytes. The range of the CD4/CD8-positive cell ratio differed according to the lesions. Increased LC density was associated with the severity of CD3-positive cell infiltration. Ki-67- and Topo II-LI showed various degrees of epithelial immunoreactivity. There was a significant correlation between LC density and proliferative potential of the epithelium in periapical lesions. CONCLUSION: These findings suggested that LCs appeared to be associated with T lymphocyte infiltration and proliferative potential of the epithelial tissue in periapical lesions. |
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Authors:
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T Suzuki; H Kumamoto; K Ooya; K Motegi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Oral diseases Volume: 7 ISSN: 1354-523X ISO Abbreviation: Oral Dis Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 336-43 Citation Subset: D |
Affiliation:
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Division of Maxillofacial and Plastic Surgery, Department of Oro-Maxillofacial Surgical Science, Tohoku University Graduate School of Dentistry, Sendai, Japan. takahiro@mail.cc.tohoku.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD1 / analysis* Antigens, CD3 / analysis Antigens, Neoplasm B-Lymphocytes / immunology, pathology CD4-CD8 Ratio Cell Count Cell Division DNA Topoisomerases, Type II, Eukaryotic / analysis DNA-Binding Proteins Epithelial Cells / immunology Epithelium / immunology, pathology Female Humans Immunohistochemistry Isoenzymes / analysis Ki-67 Antigen / analysis Langerhans Cells / immunology* Lymphocyte Count Macrophages / immunology, pathology Male Middle Aged Periapical Diseases / immunology*, pathology Periapical Granuloma / immunology, pathology Periodontal Ligament / immunology, pathology Plasma Cells / immunology, pathology Radicular Cyst / immunology, pathology Statistics, Nonparametric T-Lymphocytes / immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1; 0/Antigens, CD3; 0/Antigens, Neoplasm; 0/CD1a antigen; 0/DNA-Binding Proteins; 0/Isoenzymes; 0/Ki-67 Antigen; EC 5.99.1.-/DNA Topoisomerases, Type II, Eukaryotic; EC 5.99.1.3/DNA topoisomerase II alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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