Document Detail


Immunohistochemical profile of human pancreatic pacinian corpuscles.
MedLine Citation:
PMID:  19910838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery. METHODS: We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins. RESULTS: Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile. CONCLUSIONS: Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.
Authors:
Olivia García-Suárez; Marta G Calavia; Francisco J Pérez-Moltó; Covadonga Alvarez-Abad; Pablo Pérez-Piñera; Juan M Cobo; José A Vega
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  39     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-10     Citation Subset:  IM    
Affiliation:
From the *Departamento de Morfología y Biología Celular, Universidad de Oviedo, 33006 Oviedo, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Epithelial Sodium Channel / metabolism
Glial Fibrillary Acidic Protein / metabolism
Humans
Immunohistochemistry
Male
Middle Aged
Mucin-1 / metabolism
Nerve Tissue Proteins / metabolism
Pacinian Corpuscles / metabolism*,  ultrastructure
Pancreas / metabolism*,  ultrastructure
Receptor, trkB / metabolism
Receptors, Growth Factor / metabolism
Sensory Receptor Cells / metabolism
Chemical
Reg. No./Substance:
0/Epithelial Sodium Channel; 0/Glial Fibrillary Acidic Protein; 0/Mucin-1; 0/Nerve Tissue Proteins; 0/Receptors, Growth Factor; 0/degenerin epithelial sodium channels; EC 2.7.10.1/Receptor, trkB

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