| The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma. | |
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MedLine Citation:
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PMID: 20711264 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. beta-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. beta-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the beta-Catenin expression are still controversial. OBJECTIVE: We wanted to evaluate the pattern and the intracellular localization of the beta-Catenin expression in pilomatricoma by performing immunohistochemical staining. METHODS: Twenty-seven paraffin-embedded tissue samples that were diagnosed as pilomatricoma were immunohistochemically stained with beta-Catenin antibody. RESULTS: Basaloid cells were found 15 samples of the total 27 pilomatricomas. All (15/15) of the basaloid cells strongly expressed beta-Catenin, but the transitional cells and the shadow cells did not. In the basaloid cells, the nuclei and membranes showed prominent beta-Catenin immunoreactivities, but the cytoplasm showed weak beta-Catenin immunoreactivity. CONCLUSION: This study confirmed that the nucleus and membrane of all the basaloid cells in the pilomatricomas showed a strong beta-Catenin expression, but the transitional cells and shadow cells showed negative beta-Catenin immunoreactivity. |
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Authors:
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Young Sik Kim; Dong Hoon Shin; Jong Soo Choi; Ki-Hong Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-08-05 |
Journal Detail:
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Title: Annals of dermatology Volume: 22 ISSN: 2005-3894 ISO Abbreviation: Ann Dermatol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8916577 Medline TA: Ann Dermatol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: - |
Affiliation:
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Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea. |
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