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The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma.
MedLine Citation:
PMID:  20711264     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. beta-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. beta-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the beta-Catenin expression are still controversial.
OBJECTIVE: We wanted to evaluate the pattern and the intracellular localization of the beta-Catenin expression in pilomatricoma by performing immunohistochemical staining.
METHODS: Twenty-seven paraffin-embedded tissue samples that were diagnosed as pilomatricoma were immunohistochemically stained with beta-Catenin antibody.
RESULTS: Basaloid cells were found 15 samples of the total 27 pilomatricomas. All (15/15) of the basaloid cells strongly expressed beta-Catenin, but the transitional cells and the shadow cells did not. In the basaloid cells, the nuclei and membranes showed prominent beta-Catenin immunoreactivities, but the cytoplasm showed weak beta-Catenin immunoreactivity.
CONCLUSION: This study confirmed that the nucleus and membrane of all the basaloid cells in the pilomatricomas showed a strong beta-Catenin expression, but the transitional cells and shadow cells showed negative beta-Catenin immunoreactivity.
Authors:
Young Sik Kim; Dong Hoon Shin; Jong Soo Choi; Ki-Hong Kim
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Publication Detail:
Type:  Journal Article     Date:  2010-08-05
Journal Detail:
Title:  Annals of dermatology     Volume:  22     ISSN:  2005-3894     ISO Abbreviation:  Ann Dermatol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8916577     Medline TA:  Ann Dermatol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  -    
Affiliation:
Department of Dermatology, College of Medicine, Yeungnam University, Daegu, Korea.
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