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Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (<i>Citellus dauricus</i> Brandt) Ovary.
MedLine Citation:
PMID:  22673204     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and Western blot have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (α, β<inf>A</inf> and β<inf>B</inf>). In the breeding season ovary, all three subunits were present in granulosa cells, theca cells of antral follicles and interstitial cells, with the strongest immunostaining in granulosa cells. Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. In the nonbreeding season ovary, inhibin/activin α and β<inf>A</inf> subunits were weakly immunopositive in granulosa cells of early stage follicles, while β<inf>B </inf>subunit was undetectable. The expression level of inhibin/activin subunit proteins were generally higher in the ovaries of the breeding season, and then decreased to a relatively low level during the nonbreeding season. The dynamic expression of inhibin/activin subunits indicated that they might play important paracrine and/or autocrine role(s) during the seasonal folliculogenesis of the wild ground squirrel.
Authors:
Xia Sheng; Jiaju Weng; Haolin Zhang; Xiaonan Li; Mengyuan Zhang; Meiyu Xu; Qiang Weng; Gen Watanabe; Kazuyoshi Taya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-05
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  -     ISSN:  1348-4400     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China.
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