Document Detail

Immunohistochemical and Immunoelectron Study of Major Histocompatibility Complex Class-II Antigen in Canine Cutaneous Histiocytoma: Its Relation to Tumor Regression.
MedLine Citation:
PMID:  23422487     Owner:  NLM     Status:  In-Data-Review    
In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. All tumors expressed MHC class-II, and two major staining patterns were identified: focal juxtanuclear cytoplasmic staining and rim-like staining along the cell periphery. The MHC class-II labelling pattern and T- and B-lymphocyte infiltrates were associated with tumor regression. In regressing lesions, MHC class-II molecules shift to the cell surface and an increase of both T- and B-lymphocytes were noted. The increasing expression of MHC class-II molecules on the cell surface could be a significant factor for the onset and progression of tumour regression.
Isabel Pires; Paula Rodrigues; Anabela Alves; Felisbina Luisa Queiroga; Filipe Silva; Carlos Lopes
Related Documents :
10602497 - Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associate...
15748637 - The role of uv induced lesions in skin carcinogenesis: an overview of oncogene and tumo...
10952247 - Establishment and characterization of a spontaneously immortalized myofibroblast cell l...
9331837 - Does vats favor seeding of carcinoma of the lung more than a conventional operation?
12686457 - Parathyroid hormone-related protein upregulates integrin expression via an intracrine p...
25427907 - Understanding the tumor suppressor pten in chronic alcoholism and hepatocellular carcin...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Department of Veterinary Sciences. University of Trás-os-Montes and Alto Douro, 5000-911 Vila Real, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  No Compensation in CD44 Stem Cell Marker Following BCL-2 Suppression By Antisense Oligonucleotides.
Next Document:  Activity of T-Helper Cells in Patients with Primary Sjogren's Syndrome.