Document Detail

Immunohistochemical and Immunoelectron Study of Major Histocompatibility Complex Class-II Antigen in Canine Cutaneous Histiocytoma: Its Relation to Tumor Regression.
MedLine Citation:
PMID:  23422487     Owner:  NLM     Status:  In-Data-Review    
In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. All tumors expressed MHC class-II, and two major staining patterns were identified: focal juxtanuclear cytoplasmic staining and rim-like staining along the cell periphery. The MHC class-II labelling pattern and T- and B-lymphocyte infiltrates were associated with tumor regression. In regressing lesions, MHC class-II molecules shift to the cell surface and an increase of both T- and B-lymphocytes were noted. The increasing expression of MHC class-II molecules on the cell surface could be a significant factor for the onset and progression of tumour regression.
Isabel Pires; Paula Rodrigues; Anabela Alves; Felisbina Luisa Queiroga; Filipe Silva; Carlos Lopes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Department of Veterinary Sciences. University of Trás-os-Montes and Alto Douro, 5000-911 Vila Real, Portugal.
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