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Immunohistochemical and Fluorescence In Situ Hybridization Studies on Noninvasive and Invasive Extramammary Paget's Disease.
MedLine Citation:
PMID:  23001873     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To determine useful immunohistochemical markers for tumor cells in extramammary Paget's disease (EMPD), immunohistochemical (IHC) examinations in 17 patients with EMPD, including 4 patients with dermal invasion, were performed. Among the antibodies examined, cytokeratin 7 (CK7) and CK19 were strongly positive for both intraepidermal and dermally invasive tumor cells in all patients. CAM5.2 and mucin 1 (MUC1) were also good markers. Although IHC examination revealed positive for HER-2 in 4 EMPD patients with dermal invasion, 4 out of 13 noninvasive patients were IHC negative. Fluorescence in situ hybridization (FISH) study revealed negative results for HER-2 gene amplification in 8 IHC positive patients, including each 4 patients of both noninvasive and dermal invasive cases. Our results show that besides CK7, CK19 is another favorable marker of tumor cells of EMPD. Four patients with dermal invasion were strongly positive for HER-2, although negative results were obtained in the FISH study. Further investigations are required to confirm the results of the FISH study.
Authors:
Tomonori Hikita; Yuji Ohtsuki; Toshiharu Maeda; Mutsuo Furihata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  20     ISSN:  1940-2465     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-8     Citation Subset:  IM    
Affiliation:
1Kochi Medical School, Kochi University, Matsuyama, Kochi, Japan.
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