| Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma. | |
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MedLine Citation:
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PMID: 22311377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions. |
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Authors:
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Bruno Augusto Benevenuto de Andrade; Jorge Esquiche León; Román Carlos; Wilson Delgado-Azañero; Adalberto Mosqueda-Taylor; Oslei Paes de Almeida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-05 |
Journal Detail:
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Title: Head and neck pathology Volume: 6 ISSN: 1936-0568 ISO Abbreviation: Head Neck Pathol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-20 Completed Date: 2012-12-31 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 101304010 Medline TA: Head Neck Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 297-304 Citation Subset: IM |
Affiliation:
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Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira 901, P.O. Box 52, 13414-903, Piracicaba, São Paulo, Brazil. augustodelima33@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cyclin D1 / analysis, biosynthesis Cyclin-Dependent Kinase Inhibitor p21 / analysis, biosynthesis Cyclin-Dependent Kinase Inhibitor p27 / analysis, biosynthesis Female Humans Immunohistochemistry Male Melanoma / diagnosis, metabolism* Middle Aged Mouth Neoplasms / diagnosis, metabolism* Neoplasm Proteins / analysis, biosynthesis Nevus / diagnosis, metabolism* Tumor Markers, Biological / analysis* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/CCND1 protein, human; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Neoplasm Proteins; 0/P16 protein, human; 0/Tumor Markers, Biological; 136601-57-5/Cyclin D1; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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