Document Detail

Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma.
MedLine Citation:
PMID:  22311377     Owner:  NLM     Status:  MEDLINE    
The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions.
Bruno Augusto Benevenuto de Andrade; Jorge Esquiche León; Román Carlos; Wilson Delgado-Azañero; Adalberto Mosqueda-Taylor; Oslei Paes de Almeida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-05
Journal Detail:
Title:  Head and neck pathology     Volume:  6     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2012-12-31     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-304     Citation Subset:  IM    
Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira 901, P.O. Box 52, 13414-903, Piracicaba, São Paulo, Brazil.
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MeSH Terms
Cyclin D1 / analysis,  biosynthesis
Cyclin-Dependent Kinase Inhibitor p21 / analysis,  biosynthesis
Cyclin-Dependent Kinase Inhibitor p27 / analysis,  biosynthesis
Melanoma / diagnosis,  metabolism*
Middle Aged
Mouth Neoplasms / diagnosis,  metabolism*
Neoplasm Proteins / analysis,  biosynthesis
Nevus / diagnosis,  metabolism*
Tumor Markers, Biological / analysis*
Young Adult
Reg. No./Substance:
0/CCND1 protein, human; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Neoplasm Proteins; 0/P16 protein, human; 0/Tumor Markers, Biological; 136601-57-5/Cyclin D1; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27

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