Document Detail

Immunohistochemical Expression of p16 in Pleomorphic Salivary Adenoma.
MedLine Citation:
PMID:  23354794     Owner:  NLM     Status:  Publisher    
Objective: This study aimed to characterize alteration in the immunohistochemical expression of p16 in normal tissue of the salivary gland surrounding pleomorphic adenoma, and the tumor cells of pleomorphic adenomas. Material and Method: A selected series of 120 cases of pleomorphic adenomas were examined. Results: The results showed that p16 expression in non tumor duct cells was strong positive nuclear staining in 98 (81.6%) cases out of 120, while there were 20 (16.6%) with moderate staining, and 2 (1.6%) with weak staining in the components of normal tissue of the salivary gland surrounding pleomorphic adenoma. p16 expression in pleomorphic adenomas showed 71 (59.1%) cases with moderate nuclear staining in the duct cells, 45 (37.5%) cases with nuclear weak staining, and 4 (3.3%) cases with negative staining. p16 nuclear staining in myxochondroid tissue was identified in 4 (3.3%) cases with strong staining, 65 (54.1%) cases had moderate staining, and 51 (42.5%) cases had weak staining. Conclusion: This study suggests alteration of p16 expression in pleomorphic adenomas. P16 might have a role in the development of pleomorphic adenoma.
Bassel Tarakji; Kusai Baroudi; Shorouk Darwish; Salah Sakka; Salah Hanouneh
Related Documents :
23595544 - Chordoid meningioma: a retrospective series of seven consecutive cases.
24638394 - Sarcoidosis presenting as bilateral leg lymphedema: a case report.
24137454 - Vertebroepidural metastasis of an ethmoid adenocarcinoma: a case report.
24803834 - Solitary plexiform neurofibroma of the stomach: a case report.
22371854 - Adult-onset cerebral folate deficiency.
14671974 - Four-color flow cytometry identifies virtually all cytogenetically abnormal bone marrow...
Publication Detail:
Journal Detail:
Title:  Turk patoloji dergisi     Volume:  29     ISSN:  1018-5615     ISO Abbreviation:  Turk Patoloji Derg     Publication Date:  2013  
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440471     Medline TA:  Turk Patoloji Derg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  36-40     Citation Subset:  -    
Department of Oral Pathology, Aleppo University, Faculty of Dentistry, SYRIA.
Vernacular Title:
Tükürük Bezinin Pleomorfik Adenomunda İmmünohistokimyasal p16 Ekspresyonu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Prognostic Value of Tumor-Stroma Proportion in Laryngeal Squamous Cell Carcinoma.
Next Document:  Histopathologic Analysis of Female Genital Tuberculosis: A Fifteen-Year Retrospective Study of 110 C...