| Immunohistochemical Expression and Prognostic Significance of HIF-1α and VEGF-C in Neuroendocrine Breast Cancer. | |
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MedLine Citation:
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PMID: 23225420 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC. RESULTS: The HIF-1α expression in NEBC was predominantly negative, with only 5 (16.1%) cases showing strong reaction to HIF-1α. Eighteen (58.0%) NEBC cases showed moderate-to-strong VEGF-C expression. VEGF-C expression negatively correlated with progesterone receptor positivity (p=0.014) and duration of follow-up (p=0.021). A multivariate Cox proportional hazard regression analysis showed that HIF-1α (p=0.019) was a significant predictor of disease-free survival, whereas VEGF-C (p=0.099) showed no such association. CONCLUSION: HIF-1α overexpression indicated unfavourable prognosis and could serve as an additional prognostic factor in NEBC. Moreover, patients with NEBC exhibiting moderate or strong VEGF-C expression could be candidates for a specific VEGF-C antibody therapy. |
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Authors:
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Ingrid Marton; Fabijan Knezevic; Snjezana Ramic; Milan Milosevic; Davor Tomas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5227-32 Citation Subset: IM |
Affiliation:
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Clinic for Gynaecology and Obstetrics, Sveti Duh University Hospital, Sveti Duh 64, 10 000 Zagreb, Croatia. ingridmarton@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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