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Immunohistochemical Expression and Prognostic Significance of HIF-1α and VEGF-C in Neuroendocrine Breast Cancer.
MedLine Citation:
PMID:  23225420     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC.
RESULTS: The HIF-1α expression in NEBC was predominantly negative, with only 5 (16.1%) cases showing strong reaction to HIF-1α. Eighteen (58.0%) NEBC cases showed moderate-to-strong VEGF-C expression. VEGF-C expression negatively correlated with progesterone receptor positivity (p=0.014) and duration of follow-up (p=0.021). A multivariate Cox proportional hazard regression analysis showed that HIF-1α (p=0.019) was a significant predictor of disease-free survival, whereas VEGF-C (p=0.099) showed no such association.
CONCLUSION: HIF-1α overexpression indicated unfavourable prognosis and could serve as an additional prognostic factor in NEBC. Moreover, patients with NEBC exhibiting moderate or strong VEGF-C expression could be candidates for a specific VEGF-C antibody therapy.
Authors:
Ingrid Marton; Fabijan Knezevic; Snjezana Ramic; Milan Milosevic; Davor Tomas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5227-32     Citation Subset:  IM    
Affiliation:
Clinic for Gynaecology and Obstetrics, Sveti Duh University Hospital, Sveti Duh 64, 10 000 Zagreb, Croatia. ingridmarton@gmail.com.
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