Document Detail


Immunohistochemical Expression of Perforin in Lichen Planus Lesions.
MedLine Citation:
PMID:  25269012     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Lichen planus (LP) is a chronic inflammatory papulosquamous skin disease characterized by epidermal basal cell damage and a particular band-like infiltrate predominantly of T cells in the upper dermis. It is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8+ cytotoxic T lymphocytes and natural killer cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in LP. Aim: Is to study the expression and distribution of perforin in the epidermis and dermis of lesional LP skin. Materials and methods: Skin biopsy specimens from lesional skin of 31 patients with LP and 10 healthy persons were analyzed by immunohistochemistry. Results: Significant accumulation of perforin + cells was found in both epidermis and dermis of LP lesions compared with healthy skin. Perforin expression was significantly upregulated in the epidermis of LP lesions. Conclusion: Accumulation of perforin + cells in the epidermis of LP lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.
Authors:
Mohamed Abdelwahed Gaber; Alaa Hassan Maraee; Dalia Rifaat Alsheraky; Marwa Hussain Abdel Azeem
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-30
Journal Detail:
Title:  Ultrastructural pathology     Volume:  -     ISSN:  1521-0758     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-30     Completed Date:  -     Revised Date:  2014-10-1    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-7     Citation Subset:  -    
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