Document Detail

Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters.
MedLine Citation:
PMID:  20096418     Owner:  NLM     Status:  MEDLINE    
Neoplastic diseases in cetaceans are considered relatively uncommon. This report describes a gastric squamous cell carcinoma in an adult male harbour porpoise (Phocoena phocoena) stranded on the North Sea coast of Schleswig-Holstein, Germany. The tumour arose from the squamous epithelium of the first compartment of the stomach and metastases were found in the pulmonary and retropharyngeal lymph nodes, liver, lung and brain. Neoplastic epithelial cells expressed cytokeratin (CK) 5, CK6 and CK10. This pattern of CK expression did not differ from that of normal porpoise squamous gastric mucosa and partially shares the CK profile of human oesophageal epithelium. Tumour cells strongly expressed p53, suggesting a possible role for this tumour suppressor gene in tumourigenesis.
U Siebert; I Hasselmeier; P Wohlsein
Related Documents :
8623898 - Squamous cell carcinoma of the eyelid and the acquired immunodeficiency syndrome.
1281758 - Head and neck spindle cell carcinoma: an evaluation of current management.
10828318 - Inhibitors of the enzyme purine nucleoside phosphorylase as potential therapy for psori...
15481108 - Squamous cell carcinoma with sarcomatous stroma in the nasal cavity of a dog.
12399048 - Movement on the cell surface of the gliding bacterium, mycoplasma mobile, is limited to...
12042348 - Cytoskeletal actin microfilaments and the transient outward potassium current in hypert...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Journal of comparative pathology     Volume:  143     ISSN:  1532-3129     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2010 Aug-Oct
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Research and Technology Centre Westcoast (FTZ), University of Kiel, Büsum, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / metabolism,  secondary,  veterinary
Carcinoma, Squamous Cell / metabolism,  secondary,  veterinary*
Hematologic Neoplasms / metabolism,  veterinary
Keratins / metabolism*
Liver Neoplasms / metabolism,  secondary,  veterinary
Lung Neoplasms / metabolism,  secondary,  veterinary
Pharynx / immunology
Stomach Neoplasms / metabolism,  pathology,  veterinary*
Tumor Suppressor Protein p53 / metabolism*
Reg. No./Substance:
0/Tumor Suppressor Protein p53; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Abdominal fibrosarcoma associated with a retained surgical swab in a dog.
Next Document:  Hippocampal volume changes in healthy subjects at risk of unipolar depression.