Document Detail


Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters.
MedLine Citation:
PMID:  20096418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neoplastic diseases in cetaceans are considered relatively uncommon. This report describes a gastric squamous cell carcinoma in an adult male harbour porpoise (Phocoena phocoena) stranded on the North Sea coast of Schleswig-Holstein, Germany. The tumour arose from the squamous epithelium of the first compartment of the stomach and metastases were found in the pulmonary and retropharyngeal lymph nodes, liver, lung and brain. Neoplastic epithelial cells expressed cytokeratin (CK) 5, CK6 and CK10. This pattern of CK expression did not differ from that of normal porpoise squamous gastric mucosa and partially shares the CK profile of human oesophageal epithelium. Tumour cells strongly expressed p53, suggesting a possible role for this tumour suppressor gene in tumourigenesis.
Authors:
U Siebert; I Hasselmeier; P Wohlsein
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Journal of comparative pathology     Volume:  143     ISSN:  1532-3129     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2010 Aug-Oct
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Research and Technology Centre Westcoast (FTZ), University of Kiel, Büsum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms / metabolism,  secondary,  veterinary
Carcinoma, Squamous Cell / metabolism,  secondary,  veterinary*
Germany
Hematologic Neoplasms / metabolism,  veterinary
Immunohistochemistry
Keratins / metabolism*
Liver Neoplasms / metabolism,  secondary,  veterinary
Lung Neoplasms / metabolism,  secondary,  veterinary
Male
Pharynx / immunology
Phocoena*
Stomach Neoplasms / metabolism,  pathology,  veterinary*
Tumor Suppressor Protein p53 / metabolism*
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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