| Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters. | |
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MedLine Citation:
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PMID: 20096418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoplastic diseases in cetaceans are considered relatively uncommon. This report describes a gastric squamous cell carcinoma in an adult male harbour porpoise (Phocoena phocoena) stranded on the North Sea coast of Schleswig-Holstein, Germany. The tumour arose from the squamous epithelium of the first compartment of the stomach and metastases were found in the pulmonary and retropharyngeal lymph nodes, liver, lung and brain. Neoplastic epithelial cells expressed cytokeratin (CK) 5, CK6 and CK10. This pattern of CK expression did not differ from that of normal porpoise squamous gastric mucosa and partially shares the CK profile of human oesophageal epithelium. Tumour cells strongly expressed p53, suggesting a possible role for this tumour suppressor gene in tumourigenesis. |
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Authors:
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U Siebert; I Hasselmeier; P Wohlsein |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-21 |
Journal Detail:
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Title: Journal of comparative pathology Volume: 143 ISSN: 1532-3129 ISO Abbreviation: J. Comp. Pathol. Publication Date: 2010 Aug-Oct |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: England |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Research and Technology Centre Westcoast (FTZ), University of Kiel, Büsum, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Neoplasms / metabolism, secondary, veterinary Carcinoma, Squamous Cell / metabolism, secondary, veterinary* Germany Hematologic Neoplasms / metabolism, veterinary Immunohistochemistry Keratins / metabolism* Liver Neoplasms / metabolism, secondary, veterinary Lung Neoplasms / metabolism, secondary, veterinary Male Pharynx / immunology Phocoena* Stomach Neoplasms / metabolism, pathology, veterinary* Tumor Suppressor Protein p53 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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