Document Detail


Immunohematological findings in myelodysplastic syndrome.
MedLine Citation:
PMID:  11340246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Few immunohematological studies have been done in myelodysplastic syndrome (MDS). METHODS: Twenty-nine MDS patients were retrospectively evaluated with a direct antiglobulin test (DAT), antibody screening, serum electrophoresis and immunoelectrophoresis. Clinical and laboratory studies (hemoglobin level, reticulocyte count, DHL, total and indirect bilirubin) were done simultaneously, as well as the French-American-British subtype and bone marrow biopsy findings. RESULTS: Alloantibodies were demonstrated in 17 patients (58.6%), autoantibodies in 10 (34.4%) patients and cold agglutinin in 18 (62%) patients. DAT was mediated by only IgG in 8 patients (80%), by IgG and C3 in 1 patient (10%) and by IgG, IgA and C3 in 1 (10%) patient. No hemolytic disease occurred in patients with autoantibodies. Increased serum gammaglobulin was observed in 16 (54.4%) patients. There was no correlation between the incidence of allo-/autoantibodies and the gammaglobulin level (p = 0.937) and the presence of lymphocyte infiltrates in bone marrow biopsies (p = 0.156). No significant difference was observed when the incidence of autoantibodies and number of red blood cell transfusions were compared (p = 0.334). Patients with refractory anemia and refractory anemia with ringed sideroblasts subtypes had a higher incidence of allo-/autoantibodies than other MDS subtypes (p = 0.03). CONCLUSION: Patients with MDS, in particular refractory anemia and refractory anemia with ringed sideroblasts have a high incidence of allo- and autoantibodies, probably related to intrinsic immune disorder, without clinical or laboratory hemolysis.
Authors:
M C Novaretti; C R Sopelete; E R Velloso; M F Rosa; P E Dorlhiac-Llacer; D A Chamone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  105     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-05-31     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Hematology and Hemotherapy Deparment, University of São Paulo, School of Medicine, Fundação Pró-Sangue/Hemocentro de São Paulo, Av. Dr Enéas de Carvalho Aguiar, 155-1. andar São Paulo, Brazil. marcia.novaretti@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Agglutinins / blood
Anemia, Refractory / immunology
Anemia, Refractory, with Excess of Blasts / immunology
Autoantibodies / blood
Biopsy
Bone Marrow / pathology
Complement C3 / analysis
Coombs' Test
Cryoglobulins
Erythrocyte Transfusion
Female
Humans
Immunoelectrophoresis
Immunoglobulin A / blood
Immunoglobulin G / blood
Isoantibodies / blood
Lymphocytes / pathology
Male
Middle Aged
Myelodysplastic Syndromes / blood*,  immunology*,  pathology
Retrospective Studies
Chemical
Reg. No./Substance:
0/Agglutinins; 0/Autoantibodies; 0/Complement C3; 0/Cryoglobulins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Isoantibodies; 0/cold agglutinins

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