Document Detail

Immunoglobulins in tears and sera in patients with atopic dermatitis.
MedLine Citation:
PMID:  11332296     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate the role of circulating (i.e., present in the serum) and locally produced (i.e., in the lamina propria of mucous membranes) immunoglobulins including IgE. The IgG, IgA, IgM immunoglobulins, and IgE (total and specific) were measured in patients' sera with atopic dermatitis (AD) (n = 93). As control subjects 83 healthy volunteers, matched for sex and age, were included. The IgG and IgM levels were within the normal range. Mean value of the total IgA (2.55 +/- 0.26 g/L, in controls 1.49 +/- 0.32 g/L) and IgE (609 IU/mL, in controls below 40 IU/mL) levels were significantly elevated (p < 0.05) in sera of AD patients. Based on the serum total IgE levels (above or below 40 IU/mL) the patients were divided into RAST-positive and RAST-negative types of allergy, respectively. RAST-positive AD (n = 79) showed hypersensitivity to inhalant and food allergens determined by the specific IgE test. The majority of RAST-positive AD cases (n = 68) presented only skin manifestations, while the rest of the patients (n = 11) had rhinoconjunctivitis as well. RAST-positive AD patients with rhinoconjunctivitis showed an increased IgE level in tears (above 10 IU/mL). The specific IgE test positivity in tears correlated with elevated serum total IgE levels and specific IgE positivity (r = 0.925). Total and allergen-specific IgE in the tears can be used to diagnose allergy in vitro. It is believed that the mucosal permeability is enhanced in the atopic inflammatory process, and this may facilitate the transmission of environmental allergens.
S Somos; I Schneider; B Farkas
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  22     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Dermatology, Medical University of Pécs, Kodaly u. 20, Hungary.
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MeSH Terms
Allergens / administration & dosage,  analysis
Biological Markers / analysis
Conjunctivitis, Allergic / immunology
Dermatitis, Atopic / blood,  immunology*
Food Hypersensitivity / blood,  immunology
Immunoglobulin E / analysis
Immunoglobulins / analysis*,  blood
Middle Aged
Precipitin Tests
Radioallergosorbent Test
Rhinitis, Allergic, Perennial / immunology
Tears / immunology*
Reg. No./Substance:
0/Allergens; 0/Biological Markers; 0/Immunoglobulins; 37341-29-0/Immunoglobulin E

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