Document Detail

Immunoglobulins in saliva of preterm and full-term infants.
MedLine Citation:
PMID:  12654094     Owner:  NLM     Status:  MEDLINE    
The aim of this longitudinal study was to determine salivary levels of total IgA, IgG and IgM in 84 preterm and 214 full-term infants, from birth to 18 months of age. Unstimulated whole saliva was collected from each infant at birth, and subsequently at 3-monthly intervals. Immunoglobulin levels were estimated using an ELISA technique. At birth, IgA was detected in 147/214 (69%) full-term infants but only 47/84 (56%) preterm infants (P < 0.01). In the case of IgG, 61% of full-term and 56% of preterm infants showed detectable levels, whereas IgM was found in 71% and 73%, respectively. Levels of IgA and IgG rose from birth to 18 months, whereas IgM levels did not change significantly. Increases in salivary levels of IgA were associated with introduction of solid foods (P < 0.001), as well as tooth eruption (P < 0.001). Our results indicate that the majority of full-term and preterm infants are orally immunocompetent at birth.
A K L Wan; W K Seow; D M Purdie; P S Bird; L J Walsh; D I Tudehope
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  18     ISSN:  0902-0055     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  D    
University of Queensland, School of Dentistry, Brisbane, Queensland, Australia.
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MeSH Terms
Chi-Square Distribution
Gestational Age
Immunocompetence / immunology
Immunoglobulin A, Secretory / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Immunoglobulins / analysis*
Infant Food
Infant, Newborn / metabolism*
Infant, Premature / metabolism*
Longitudinal Studies
Saliva / immunology*
Statistics, Nonparametric
Tooth Eruption
Reg. No./Substance:
0/Immunoglobulin A, Secretory; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins

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