| Immunoglobulins (IgG, IgA, IgM, IgE) and complement components (C3, C4) in nephrotic syndrome due to minimal change and other forms of glomerulonephritis, a clue for steroid therapy? | |
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MedLine Citation:
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PMID: 3696317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum IgG, IgA, IgM, IgE, C3 and C4 were measured in 13 patients with minimal change (MC) glomerulonephritis and 10 with the nephrotic syndrome (NS) due to other forms of glomerulonephritis. The tests were repeated in all patients with MC glomerulonephritis when they went into remission. Serum IgG was reduced, IgM, IgE and C3 were raised while serum IgA was within the normal range when the patients were nephrotic. Changes in serum immunoglobulins and complement components were not specific to MC glomerulonephritis and these parameters reverted towards normal when the NS went into remission. Elevated C3 levels probably reflected increased hepatic protein synthesis since C3 correlated significantly with serum cholesterol. There was a tendency for serum IgE concentrations to positively correlate with the total dose of prednisolone required to bring the NS to remission. |
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Authors:
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M K Chan; K W Chan; B Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 47 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1987 |
Date Detail:
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Created Date: 1988-01-27 Completed Date: 1988-01-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 125-30 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Hong Kong, Queen Mary Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Cholesterol / blood Complement System Proteins / analysis* Female Glomerulonephritis / complications*, drug therapy Humans Immunoglobulins / analysis* Male Middle Aged Nephrosis, Lipoid / drug therapy, immunology* Nephrotic Syndrome / drug therapy, etiology, immunology* Prednisolone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 50-24-8/Prednisolone; 57-88-5/Cholesterol; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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