| Immunoglobulin treatment versus plasma exchange in patients with chronic moderate to severe myasthenia gravis. | |
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MedLine Citation:
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PMID: 11843764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to compare the efficacy of high-dose intravenous immunoglobulin (IVIG) treatment with plasma exchange in patients suffering from moderate to severe myasthenia gravis (MG) in a stable phase. There are no controlled studies comparing IVIG with plasma exchange in patients who despite immunosuppressive treatment have persistent incapacitating MG symptoms. This was a controlled crossover study. Twelve patients with generalized moderate to severe MG on immunosuppressive treatment for at least 12 months were included. The patients were evaluated clinically using a quantified MG clinical score (QMGS) before and at follow-up visits after each treatment. One week after the treatments, the patients who received plasma exchange treatment showed a significant improvement in QMGS compared to baseline but although some improvement was seen after IVIG this did not reach statistical significance. Four weeks after both plasma exchange and IVIG treatments, there was a significant improvement in QMGS compared to baseline. One week and 4 weeks after treatment, no significant difference between the 2 treatments was found. Both treatments have a clinically significant effect 4 weeks out in patients with chronic MG, but the improvement has a more rapid onset after plasma exchange than after IVIG. |
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Authors:
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J Rønager; M Ravnborg; I Hermansen; S Vorstrup |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 25 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-02-14 Completed Date: 2002-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 967-73 Citation Subset: IM |
Affiliation:
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Department of Neurology, Neuroscience Center, National University Hospital, Copenhagen, Denmark. jronager@vip.cybercity.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chronic Disease Cross-Over Studies Electromyography Female Humans Immunoglobulins, Intravenous / therapeutic use* Immunosuppressive Agents / therapeutic use Male Middle Aged Myasthenia Gravis / therapy* Plasma Exchange* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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