Document Detail


Immunoglobulin-secreting cells in SLE: correlation with disease activity.
MedLine Citation:
PMID:  7009856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood lymphocytes which contain and secret immunoglobulin were identified by fluorescent staining and a reverse hemolytic plaque assay. Significantly increased numbers of these cells were found in patients with active systemic lupus erythematosus compared with patients with rheumatoid arthritis, bacterial infections and normal controls. The increased numbers of these circulating activated B cells closely correlated with clinical and laboratory indices of disease activity, indicating their potential value in the management of lupus patients. However, the demonstration of pseudo-plaques in assays of lymphocytes from some lupus patients emphasizes the need to establish the true secreting nature of the plaques detected.
Authors:
P L Tan; G T Pang; G Cullinane; J D Wilson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  7     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:    1980 Nov-Dec
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  807-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibody-Producing Cells*
B-Lymphocytes
Hemolytic Plaque Technique
Humans
Lupus Erythematosus, Systemic / immunology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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