Document Detail

Immunoglobulin responses to a repeated bout of downhill running.
MedLine Citation:
PMID:  16920774     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of downhill running on immunoglobulin responses.
METHOD: Eleven untrained men performed 2 x 60 minute bouts of downhill running (-13.5% gradient), at a speed eliciting 75% of their vO2peak on a level grade. Two runs were spaced 14 days apart. Serum samples were collected before, after, and every hour for 12 hours and every 24 hours for six days. Serum total creatine kinase and immunoglobulin isotypes and subclasses were measured, and results were analysed using a repeated measures analysis of variance (12 hour period, 2 x 14; 24 hour intervals, 2 x 6, p < or = 0.05).
RESULTS: There was a significant interaction effect for creatine kinase (activity lower after run 2 than after run 1, 6-24 h) and exercise effect, with the serum concentrations of IgG1, IgG2, IgG4, and IgE lower, and IgM higher, after run 2.
CONCLUSION: Lower concentrations of IgG1, IgG2, and IgE after run 2 may reflect a dampened autoimmune inflammatory response to autoantigens and enhanced autoantigen clearance mediated by the upregulation of IgM.
A J McKune; L L Smith; S J Semple; B Mokethwa; A A Wadee
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Publication Detail:
Type:  Journal Article     Date:  2006-08-18
Journal Detail:
Title:  British journal of sports medicine     Volume:  40     ISSN:  1473-0480     ISO Abbreviation:  Br J Sports Med     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-05     Completed Date:  2006-11-09     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  844-9     Citation Subset:  IM    
Tshwane University of Technology, Sport and Physical Rehabilitation Sciences, Pretoria 0001, South Africa.
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MeSH Terms
Analysis of Variance
Creatine Kinase / blood*
Exercise Test / methods
Immunoglobulins / blood*
Muscle, Skeletal / physiology*
Oxygen Consumption / physiology
Physical Exertion / physiology
Running / physiology*
Reg. No./Substance:
0/Immunoglobulins; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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