Document Detail

Immunoglobulin-producing cells in the inflammatory infiltrates of cutaneous tumors. Immunocytologic identification in situ.
MedLine Citation:
PMID:  325148     Owner:  NLM     Status:  MEDLINE    
An immunocytochemical technique has been developed for the identification in situ of immunoglobulin-producing cells in tissues fixed in Bouin's solution and embedded in paraffin. Technical details are discussed as well as the application of the technique to the study of plasma cells in the inflammatory infiltrate around cutaneous tumors. Preliminary results have been obtained with basal cell epitheliomas, squamous cell carcinomas, and malignant melanomas. IgA-producing cells were present in all tumors. IgG-producing cells were present in variable frequency, depending on the type of tumor, and IgM-producing cells were found only in basal cell epitheliomas and squamous cell carcinomas.
R Bustamante; D Schmitt; C Pillet; J Thivolet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  68     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody-Producing Cells / immunology*
Carcinoma, Basal Cell / immunology*,  pathology
Carcinoma, Squamous Cell / immunology*,  pathology
Cytological Techniques
Immunoglobulin A
Immunoglobulin M
Immunologic Techniques
Melanoma / immunology*,  pathology
Palatine Tonsil / immunology,  pathology
Skin Neoplasms / immunology*,  pathology
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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