| Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. | |
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MedLine Citation:
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PMID: 12956761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Henoch-Schönlein purpura is characterized by immunoglobulin A1 (IgA1) depositions in blood vessels of the skin or in glomeruli, resulting from altered hinge region O-glycosylation. Henoch-Schönlein purpura is seldom reported as a complication of IgA1 myeloma, even when the circulating IgA concentration is very high. We report two patients with IgA1 myeloma presenting with Henoch-Schönlein purpura. The O-glycosylation of these patients' IgA1 was studied. Both patients showed increased binding to peanut agglutinin lectin, suggesting a low degree of sialylation of the hinge region of IgA1 that was confirmed by mass spectrometry. IgA multiple myeloma, secreting IgA1 molecules with decreased sialylation, presenting with a Henoch-Schönlein purpura-like syndrome was diagnosed. |
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Authors:
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Annette H M Van Der Helm-Van Mil; Alice C Smith; Shideh Pouria; Edward Tarelli; Nigel J Brunskill; Heroen C J Eikenboom |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 122 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-05 Completed Date: 2003-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 915-7 Citation Subset: IM |
Affiliation:
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Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. AvdHelm@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Glycosylation Humans Immunoglobulin A / blood* Male Middle Aged Multiple Myeloma / blood, complications* Purpura, Schoenlein-Henoch / blood, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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