| Immunoglobulin light chain gene rearrangements in precursor-B-acute lymphoblastic leukemia: characteristics and applicability for the detection of minimal residual disease. | |
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MedLine Citation:
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PMID: 16627258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed the frequency and characteristics of Vk-Jk and Vlambda-Jlambda rearrangements inpatients with precursor-B-acute lymphoblastic leukemia (ALL) and evaluated the applicability of these rearrangements as targets for minimal residual disease (MRD) detection. Using the BIOMED-2 primer sets, Vk-Jk and Vlambda-Jlambda rearrangements were detected in 30% and 17% of patients, respectively. Vk-Jk rearrangements were particularly frequent in common-ALL, children between 5-10 years, and TEL-AML1-positive patients. Vk-Jk and Vlambda-Jlambda rearrangements showed a good stability between diagnosis and relapse and reached good sensitivities in real-time quantitative polymerase chain reaction analysis. Our data show that Vk-Jk and Vlambda-Jlambda rearrangements can be successfully applied for MRD detection in a subset of patients with precursor-B-ALL. |
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Authors:
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Vincent H J van der Velden; Maaike de Bie; Elisabeth R van Wering; Jacques J M van Dongen |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-19 |
Journal Detail:
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Title: Haematologica Volume: 91 ISSN: 1592-8721 ISO Abbreviation: Haematologica Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-03 Completed Date: 2006-08-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: Italy |
Other Details:
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Languages: eng Pagination: 679-82 Citation Subset: IM |
Affiliation:
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Department of Immunology, Erasmus MC, Rotterdam, The Netherlands. v.h.j.vandervelden@erasmusmc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bone Marrow / pathology Child Child, Preschool Computer Systems DNA Primers DNA, Neoplasm / genetics* Female Gene Rearrangement, B-Lymphocyte Gene Rearrangement, B-Lymphocyte, Light Chain* Gene Rearrangement, T-Lymphocyte Genes, Immunoglobulin Humans Immunoglobulin Variable Region / genetics Infant Infant, Newborn Male Neoplasm, Residual Polymerase Chain Reaction / methods Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis, genetics*, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Neoplasm; 0/Immunoglobulin Variable Region |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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