Document Detail


Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis. Relationship to periodontal treatment.
MedLine Citation:
PMID:  1960239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Production of antibodies to collagen type I was analyzed by means of an enzyme-linked immunospot (ELISPOT) assay in patients with chronic adult periodontitis (AP) before and after periodontal hygiene treatment. Anti-collagen type I antibody-secreting cells were found among mononuclear cells enzymatically eluted from inflamed gingiva in 9 of 15 patients with untreated AP and in 4 of 14 hygiene-treated patients with a varied isotype distribution. A notably high prevalence of IgG and IgM isotypes was observed for the anti-collagen antibodies in untreated patients. With wide variation, chronic AP was characterized by a high frequency of spontaneous IgG and low numbers of IgA and IgM-producing cells. Periodontal hygiene treatment significantly reduced the number of IgA and IgM-secreting cells. Although AP is not an autoimmune disease in the accepted sense, our results indicate that local autoimmune reactions to collagen type I are common in untreated AP, implying an interplay between periodontal infection and autoimmunity.
Authors:
R Jonsson; A Pitts; C Lue; S Gay; J Mestecky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  18     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-07     Completed Date:  1992-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  703-7     Citation Subset:  D; IM    
Affiliation:
Department of Microbiology, University of Alabama, Birmingham 35294.
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MeSH Terms
Descriptor/Qualifier:
Autoantibodies / chemistry*
Collagen / immunology*
Enzyme-Linked Immunosorbent Assay
Evaluation Studies as Topic
Humans
Immunoglobulin A / immunology*
Immunoglobulin G / immunology*
Immunoglobulin Isotypes / chemistry*
Immunoglobulin M / immunology*
Periodontics / standards*
Periodontitis / immunology*,  pathology,  therapy
Grant Support
ID/Acronym/Agency:
DE-08228/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 0/Immunoglobulin M; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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