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IMMUNOGLOBULIN HEAVY CHAIN/LIGHT CHAIN PAIR MEASUREMENT IS ASSOCIATED WITH SURVIVAL IN DIFFUSE LARGE B-CELL LYMPHOMA.
MedLine Citation:
PMID:  23327290     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Elevated serum free light chains (FLC) have been associated with unfavorable prognostic in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to determine the clinical relevance of a quantitative assessment of intact circulating immunoglobulin (Ig), using serum Ig heavy chain/light chain pair (HLC) measurements in DLBCL patients. FLC and HLC were measured in 409 serums of DLBCL patients included in the LNH03-B clinical trial program of the GELA. Patients with an abnormal IgMκ/IgMλ ratio or an abnormal FLC ratio more frequently displayed adverse clinical characteristics. Patients with abnormal IgMκ/IgMλ ratios had inferior PFS and OS as compared to patients with normal ratio in the overall cohort (5y-PFS CI95% 44.9 % vs. 69.3%, p =0.0003 and 5y-0S CI95% 50.8% vs. 78.1%, p =0.0003) and in the R-CHOP cohort (5y-0S 43.5% vs. 70.3%, p =0.003). In multivariate analysis including elevated FLC/HLC and IPI, an abnormal IgMκ/IgMλ ratio (HR =1.54, CI95% 1.03-2.3, p =0.03) remained predictive of shorter progression-free survival. Gene expression profile experiments and immunohistochemistry indicate that this measurement is at least partially related to the tumor cell secretion. Both elevated serum FLC and an abnormal IgMκ/IgMλ ratio are associated with unfavorable outcomes in DLBCL patients treated by R-CHOP.
Authors:
Fabrice Jardin; Marie Hélène Delfau-Larue; Thierry Jo Molina; Christiane Copie-Bergman; Josette Brière; Tony Petrella; Danielle Canioni; Bettina Fabiani; Jean-Philippe Jais; Martin Figeac; Karen Leroy; Sylvain Mareschal; Gilles André Salles; Bertrand Coiffier; Richard Delarue; Frédéric Peyrade; André Bosly; Marc André; Nicolas Ketterer; Corinne Haioun; Hervé Tilly
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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