Document Detail


Immunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissues.
MedLine Citation:
PMID:  2117323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The theory of 'homing' mechanism has been proposed to explain the association of malignant lymphoma involving multiple sites of mucosa-associated lymphoid tissue (MALT). DNA rearrangement in the peripheral blood and bone marrow specimens of 20 patients with MALT lymphoma were studied utilizing JH and C beta gene probes, aiming to detect circulating lymphoma cells and unrecognized bone marrow involvement. Our search for malignant cells in the peripheral blood was unrewarding and the 'homing' theory remained unproven. However, the study of DNA rearrangement showed to be useful in determining the malignant nature of abnormal lymphoid aggregates found in the bone marrow of these patients.
Authors:
R Liang; V V Chan; T K Chan; D Todd; F Ho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  84     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Affiliation:
University Department of Medicine, University of Hong Kong, Queen Mary Hospital.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow / analysis,  immunology*
DNA Probes
DNA, Neoplasm / analysis,  genetics
Gene Rearrangement / genetics*
Genes, Immunoglobulin / genetics*
Humans
Lymphoid Tissue / immunology*
Lymphoma, Non-Hodgkin / genetics*,  immunology
Mucous Membrane / immunology
Chemical
Reg. No./Substance:
0/DNA Probes; 0/DNA, Neoplasm

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