Document Detail

Immunoglobulin deposition in skin of patients with lupus erythematosus: clinical correlates and indications for direct immunofluorescence.
MedLine Citation:
PMID:  3079246     Owner:  NLM     Status:  MEDLINE    
LE is associated with deposition of immunoglobulins at the DEJ of both involved and uninvolved skin. A demonstration of these deposits by direct immunofluorescence can aid the clinician in establishing the diagnosis of LE, in separating between its types, and sometimes in gauging disease activity and prognosis. However, interpretation is not simple or straightforward. When the clinician receives the results, he or she must read the descriptive information as well as the immunopathologist's interpretation. The clinician must integrate this knowledge into the clinical setting to make a final interpretation. In addition to the immunofluorescence results, the clinician must consider the clinical status of the patient; the morphology, configuration, and distribution of skin lesions; the results of laboratory tests; and the results of biopsy for ordinary histopathologic examination. Despite these limitations, biopsy of skin for direct immunofluorescence examination is a very useful procedure that aids the clinician in the diagnosis and management of patients with various forms of LE.
M V Dahl
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in dermatology     Volume:  1     ISSN:  0882-0880     ISO Abbreviation:  Adv Dermatol     Publication Date:  1986  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8606032     Medline TA:  Adv Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-66     Citation Subset:  IM    
Department of Dermatology, University of Minnesota Medical School, Minneapolis.
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MeSH Terms
Fluorescent Antibody Technique
Immunoglobulins / analysis*
Lupus Erythematosus, Systemic / immunology*
Skin / immunology*
Reg. No./Substance:

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