Document Detail

Immunoglobulin and complement in normal skin.
MedLine Citation:
PMID:  372244     Owner:  NLM     Status:  MEDLINE    
Cryostat sections of normal skin from 57 white adults were examined by direct and indirect immunofluorescence for immunoglobulins, complement factors, and transferrin. The results for basement membrane zone (BMX) were significantly different for the 11 face and 46 non-face biopsies: in the face, IgM was found in five, IgG in two, IgA in one, and C3 in none, whereas, in non-face, IgM was present in six, IgG in none, IgA in one, and C3 in five. The results for dermal vessel walls (DV) were not apparently different for face and non-face; in the 57 biopsies IgM was present in one, IgG in none, IgA in one, and C3 in one. The 11 biopsies from the face and 26 of the non-face biopsies were examined further. No IgD or C4 was identified, but one case (scalp) showed BMZ Clq, properdin, and transferrin, and in two cases (one face, one non-face) DV properdin was found. Cytoid bodies (IgM and IgA) were present in moderate numbers in one case; all other positive reactions were finely granular.
W K Blenkinsopp; R J Clayton; G P Haffenden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  31     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1143-6     Citation Subset:  AIM; IM    
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MeSH Terms
Basement Membrane / immunology
Complement System Proteins / analysis*
Fluorescent Antibody Technique
Immunoglobulins / analysis*
Skin / blood supply,  immunology*
Reg. No./Substance:
0/Immunoglobulins; 9007-36-7/Complement System Proteins

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