Document Detail


Immunoglobulin classes of antibodies in milk of swine after intranasal exposure to pseudorabies virus or transmissible gastroenteritis virus.
MedLine Citation:
PMID:  197014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiments were conducted to evaluate whether infection of the respiratory tract of pregnant swine with pseudorabies (Pr) virus would induce the secretion of immunoglobulin A (IgA) antibodies in their milk as was observed after enteric infection with transmissible gastroenteritis (TGE) virus. The immune response of sows to Pr virus inoculated intranasally and to TGE virus inoculated orally/intranasally or via a natural infection was studied. Emphasis was placed upon titers and Ig classes of Pr and TGE virus-neutralizing antibodies in colostrum and milk. All animals exposed to Pr virus (alone or in combination with TGE virus) developed Pr-neutralizing antibody titers in both serum and milk. Pr antibody titers were generally higher in colostrum than in serum, but the opposite was true in milk compared with serum, with milk titers declining markedly during lactation. In contrast, TGE antibody titers in milk from experimentally or naturally infected sows usually remained higher than the corresponding serum titers and persisted at relatively constant levels throughout lactation. Gel filtration studies of milk indicated that the antibody activity against Pr virus was associated almost entirely with IgG fractions, with small amounts of antibody detectable in IgM fractions in colostrum from two of nine sows. By comparison, TGE antibodies were primarily of the IgA class, with varying but lesser amounts of antibody associated with the IgG class. Such results suggest that viral infection of the intestinal tract of the sow, but not the upper respiratory tract, stimulates the secretion of IgA antibodies in the milk.
Authors:
L F Saif; E H Bohl
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  16     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  961-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Viral / analysis*
Colostrum / immunology
Female
Gastroenteritis, Transmissible, of Swine / immunology*,  transmission
Herpesvirus 1, Suid / immunology
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulins / analysis*
Lactation
Milk / immunology*
Pregnancy
Pregnancy Complications, Infectious / immunology*
Pseudorabies / immunology*,  transmission
Swine
Transmissible gastroenteritis virus / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulins
Comments/Corrections

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