Document Detail

Immunoglobulin allotypes Gm and Km in hematologic malignancies.
MedLine Citation:
PMID:  3349438     Owner:  NLM     Status:  MEDLINE    
Immunoglobulin allotypes of the Gm and Km systems have been compared in patients with various forms of hematologic malignancies and healthy controls of the same ethnographic background. These comparisons found an increased frequency of the haplotype Gm and a decreased frequency of Gm in patients with Hodgkin's disease; a decreased frequency of Gm in diffuse, large-cell lymphoma patients; a decreased frequency of Gm and an increased frequency of Gm in acute myeloid leukemia patients; a decreased frequency of Gm in chronic myeloid leukemia patients, and an increased frequency of the phenotype Km(1+) in chronic lymphocytic leukemia patients. These results support previous suggestions of the involvement of immunoglobulin allotypes in the susceptibility to some forms of human hematologic malignancy.
V Janardhana; D N Propert; I Cooper; M Wolf; O M Garson; J L Hopper; B J Dickson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  31     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-04-22     Completed Date:  1988-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Department of Applied Biology, Royal Melbourne Institute of Technology, Australia.
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MeSH Terms
Gene Frequency
Immunoglobulin Gm Allotypes / genetics*
Immunoglobulin Km Allotypes / genetics*
Leukemia / genetics,  immunology*
Reg. No./Substance:
0/Immunoglobulin Gm Allotypes; 0/Immunoglobulin Km Allotypes

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