Document Detail


Immunoglobulin allotypes Gm and Km in hematologic malignancies.
MedLine Citation:
PMID:  3349438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunoglobulin allotypes of the Gm and Km systems have been compared in patients with various forms of hematologic malignancies and healthy controls of the same ethnographic background. These comparisons found an increased frequency of the haplotype Gm and a decreased frequency of Gm in patients with Hodgkin's disease; a decreased frequency of Gm in diffuse, large-cell lymphoma patients; a decreased frequency of Gm and an increased frequency of Gm in acute myeloid leukemia patients; a decreased frequency of Gm in chronic myeloid leukemia patients, and an increased frequency of the phenotype Km(1+) in chronic lymphocytic leukemia patients. These results support previous suggestions of the involvement of immunoglobulin allotypes in the susceptibility to some forms of human hematologic malignancy.
Authors:
V Janardhana; D N Propert; I Cooper; M Wolf; O M Garson; J L Hopper; B J Dickson
Related Documents :
9373208 - Ultrastructural observations on bone marrow cells of 26 patients with myelodysplastic s...
16720558 - Association of plasma adiponectin concentrations with chronic lymphocytic leukemia and ...
6575218 - Glucocorticoid receptor level, terminal deoxynucleotidyl transferase activity and initi...
2737608 - In vitro chemosensitivity testing of leukemic cells: prediction of response to chemothe...
498518 - Comparison between immunofixation and crossed immunoelectrophoresis for the detection o...
24417768 - Gastric carcinoid in the absence of atrophic body gastritis and with low ki67 index: a ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  31     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-04-22     Completed Date:  1988-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Affiliation:
Department of Applied Biology, Royal Melbourne Institute of Technology, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Gene Frequency
Haplotypes
Humans
Immunoglobulin Gm Allotypes / genetics*
Immunoglobulin Km Allotypes / genetics*
Leukemia / genetics,  immunology*
Phenotype
Chemical
Reg. No./Substance:
0/Immunoglobulin Gm Allotypes; 0/Immunoglobulin Km Allotypes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sister chromatid exchange and cell cycle patterns of normal human bone marrow cells after in vitro e...
Next Document:  Binucleated cells in a human renal cell carcinoma with 34 chromosomes.