Document Detail


Immunoglobulin abnormalities in epileptic patients treated with diphenylhydantoin.
MedLine Citation:
PMID:  971887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An immunologic study was made on 170 epileptic patients treated with antiepileptic drugs. The most noteworthy finding was that the serum IgA was decreased in 22 patients, and an IgA deficiency noticed in 12 of them. The blastic transformation rate of lymphocytes in PHA-containing cultures appeared low in seven out of 12 patients. Other findings included decreased serum IgM and IgG in some patients. These abnormalities were not encountered in epileptic patients taking no anti-epileptic drugs. Therefore, they could be considered as the side effects of antiepileptic drugs. In all patients manifesting these abnormalities, diphenylhydantoin was used in common. It was surmised that the above-mentioned immunologic abnormalities caused by anti-epileptic drugs, especially diphenylhydantoin, had resulted from disorders of the antibody producing organs in the bone marrow-thymus-lymphatic system.
Authors:
S Yabuki; K Nakaya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Folia psychiatrica et neurologica japonica     Volume:  30     ISSN:  0015-5721     ISO Abbreviation:  Folia Psychiatr Neurol Jpn     Publication Date:  1976  
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372774     Medline TA:  Folia Psychiatr Neurol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  93-109     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Dysgammaglobulinemia / chemically induced*
Epilepsy / drug therapy,  immunology*
Female
Humans
Immunoglobulin A* / cerebrospinal fluid
Immunoglobulin G* / cerebrospinal fluid
Immunoglobulin M*
Immunologic Deficiency Syndromes / chemically induced*
Lymph Nodes / pathology
Lymphocyte Activation / drug effects
Male
Phenytoin / adverse effects*
Time Factors
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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