Document Detail


Immunoglobulin-specific responses to Chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection.
MedLine Citation:
PMID:  23045619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Renewed interest in chlamydia vaccination has revealed the need for a greater understanding of the seroprevalence of chlamydial infection in US populations. We used a Chlamydia trachomatis elementary body (EB)-based enzyme-linked immunosorbent assay to define the characteristics of the humoral immune response and to determine seroprevalence. Two groups were analyzed: one consisting of patients with current, laboratory confirmed, genital chlamydial infection (n = 98) and one group of individuals whose chlamydia infection history was unknown (n = 367). C. trachomatis seropositivity was detected in 90% of the infected group and in 31% of the chlamydia-unknown group. IgG1 and IgG3 comprised the predominant anti-Chlamydia serum antibody responses. Serum IgA1 responses were variably positive, and individuals were rarely positive for anti-chlamydia IgG2, IgG4 or IgA2. The magnitude of the IgG1 and IgG3 responses was greatest in female and African American individuals and was sustained for at least 6 months. Antibody responses were not serovar restricted or confounded by Chlamydia pneumoniae cross-reactivity.
Authors:
William M Geisler; Sandra G Morrison; Martha L Doemland; Shehzad M Iqbal; Jin Su; Ausra Mancevski; Edward W Hook; Richard P Morrison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  206     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-01-25     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1836-43     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Bacterial / blood*
Antigens, Bacterial / diagnostic use
Chlamydia Infections / epidemiology*,  immunology
Chlamydia trachomatis / immunology*
Enzyme-Linked Immunosorbent Assay
Ethnic Groups
Female
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Male
Middle Aged
Seroepidemiologic Studies
Sex Factors
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
K23-AI069505/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G
Comments/Corrections

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