| Immunoglobulin M and Immunoglobulin G Seronegative Q Fever: A Hypothesis for Veterans? Medically Unexplained Chronic Multi-symptom Illnesses. | |
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MedLine Citation:
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PMID: 22427048 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We present Q fever as a credible hypothesis for Gulf War Veterans? Illnesses (GWVIs) and as a possible etiology for prevalent symptomologies affecting currently serving servicemembers. Q fever is caused by the bacteria Coxiella burnetii, which is endemic throughout the Middle East. Q fever may manifest in many forms of widely varying and often inconstant symptoms. Due to false-negative interpretations in current and past diagnostic testing, Q fever has not received appropriate consideration as a possible causative agent for medically unexplained veterans? illnesses. Review of current literature invites us to consider that a form of Q fever involving an incomplete immune response is a potential cause of these debilitating illnesses. We hypothesize C. burnetii infection coincidental to exposures suppressing antibody-specific immune response results in infection mediated by immunoglobulin D (IgD). Literature indicates that successful treatment for this form of Q fever requires the concurrent administration of doxycycline and hydroxychloroquine. |
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Authors:
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Michael J Chagaris; Robert C Smith; Ami L Goldstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of special operations medicine : a peer reviewed journal for SOF medical professionals Volume: 12 ISSN: 1553-9768 ISO Abbreviation: J Spec Oper Med Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158402 Medline TA: J Spec Oper Med Country: United States |
Other Details:
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Languages: eng Pagination: 37-48 Citation Subset: IM |
Copyright Information:
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2012. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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