| Immunoglobulin G Levels Can Predict Non-Diabetic Renal Disease in Type II Diabetes Mellitus Patients. | |
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MedLine Citation:
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PMID: 22145829 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Proteinuria in patients with diabetes mellitus (DM) is sometimes caused by glomerular diseases other than diabetic nephropathy (DN). In patients with type II DM, specific predictors for non-diabetic renal disease (NDRD) are needed in addition to the traditional indicators for renal biopsy. Methods: From January 1, 2000 to March 31, 2011, we retrospectively enrolled 54 type II DM patients with proteinuria who had undergone renal biopsies. Associations between NDRD and 20 potential biomarkers, including serum levels of immunoglobulins and proteins associated with kidney function, and urinary levels of protein and red blood cells, and hepatitis virus carrier statuses were analyzed by multivariate logistic regression. Results: Multivariate logistic regression showed that reduced serum levels of immunoglobulin G (IgG) (odds ratio [OR]: 0.997; P=0.006; 95% confidence interval [CI]: 0.94-0.998) and creatinine (Cr) (OR: 0.587; P=0.014; 95% CI: 0.348-0.897) were predictors of NDRD. The area under the receiver operating characteristic curve (AUROC) confirmed the good discriminatory power of the IgG and Cr levels (AUROC = 0.857 ± 0.058; 95% CI: 0.744-0.970; P < 0.001 and AUROC = 0.838 ± 0.054; 95% confidence interval [CI]: 0.732-0.943; P < 0.001, respectively). The IgG level below which the risk for NDRD increased, as calculated by obtaining the best Youden index was 919.5 mg/dl (sensitivity, 91.7%; specificity, 83.3%), and the corresponding Cr level was 4.1 mg/dl (sensitivity, 58.3%; specificity, 96.7%). Conclusion: Serum IgG lower than 919.5 mg/dl and serum Cr level lower than 4.1 mg/dl are associated with NDRD in type II DM patients. |
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Authors:
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Cheng-Hao Weng; Ching-Chih Hu; Chun-Chen Yu; Ja-Liang Lin; Chih-Wei Yang; Cheng-Chieh Hung; Ching-Wei Hsu; Tzung-Hai Yen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: Journal of diabetes Volume: - ISSN: 1753-0407 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan Department of Hepatogastroenterology and Liver Research Unit, Chang Gung Memorial Hospital, Keelung Chang Gung University, College of Medicine, Taoyuan, Taiwan. |
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