Document Detail


Immunogenicity, safety and tolerability of heptavalent pneumococcal conjugate vaccine administered at 3, 5 and 11 months post-natally to pre- and full-term infants.
MedLine Citation:
PMID:  15705475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the immunogenicity, safety and tolerability of heptavalent pneumococcal conjugate vaccine (PCV7) administered three, five and 11 months post-natally to 46 pre-term (PT) and 46 full-term (FT) infants. After each dose, there was no significant difference between the groups in antibody levels for any of the vaccine serotypes. After the second dose, the majority of subjects in both groups showed titres of > or =0.35 microg/mL, whereas an antibody concentration of > or =1.0 microg/mL was usually reached in both PT and FT infants after the third dose. Safety and tolerability was also similar in the groups. These findings support the use of the simplified schedule that includes three doses of PCV7 in both PT and FT infants, and suggest that this may reduce costs, as well as problems related to vaccine supply and administration.
Authors:
Susanna Esposito; Lorenza Pugni; Samantha Bosis; Alice Proto; Laura Cesati; Ciro Bianchi; Carolyn Cimino; Fabio Mosca; Nicola Principi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vaccine     Volume:  23     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-11     Completed Date:  2005-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1703-8     Citation Subset:  IM    
Affiliation:
Institute of Pediatrics, University of Milan, Via Commenda 9, 20122 Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Female
Fever / economics,  etiology,  microbiology
Humans
Immunization Schedule*
Infant
Infant, Newborn
Infant, Premature
Male
Meningococcal Vaccines / administration & dosage*,  adverse effects*,  economics
Pneumococcal Vaccines / administration & dosage*,  adverse effects*,  economics
Time Factors
Vaccines, Conjugate / administration & dosage,  adverse effects,  economics
Chemical
Reg. No./Substance:
0/Meningococcal Vaccines; 0/Pneumococcal Vaccines; 0/Vaccines, Conjugate; 0/heptavalent pneumococcal conjugate vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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