Document Detail

Immunogenicity of oral poliovirus vaccine in Taiwan.
MedLine Citation:
PMID:  10634028     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that the immune response to trivalent oral poliovirus vaccine (OPV) varies widely from country to country. However, there has been no report on the immunogenicity of this vaccine in Taiwanese children. In this study, 98 children were followed up for 17 months to study the antibody responses following four doses of trivalent OPV. The results showed that, after two doses of vaccine, all children were protected against poliovirus type 1 and 2. All except two children also developed protective antibodies against poliovirus type 3. After three doses, the antibody levels in all subjects were above protective concentrations. The fourth dose, given at 18 months of age, further boosted the antibody titers. These findings show that the OPV currently used in Taiwan is highly immunogenic in Taiwanese children.
C Y Lu; C Y Lee; P I Lee; H Y Tsai; T F Chiu; H C Lin; L M Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  98     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-01     Completed Date:  2000-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  CHINA (REPUBLIC: 1949- )    
Other Details:
Languages:  eng     Pagination:  859-62     Citation Subset:  IM    
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Antibodies, Viral / analysis*
Poliovirus / immunology*
Poliovirus Vaccine, Oral / immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Poliovirus Vaccine, Oral

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