Document Detail


Immunogenicity in guinea pigs and tolerance in grass pollen-sensitive volunteers of enteric-coated grass pollen allergens.
MedLine Citation:
PMID:  3610349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An acid-insoluble, methacrylic acid, methyl methacrylate copolymer (Eudragit L-100) was used to give an enteric coating to a grass pollen extract in order to protect it against gastric degradation. Substantial protection against the degradative effects of simulated gastric secretion was demonstrated using this preparation which was well tolerated by grass pollen-allergic volunteers. The enteric-coated allergen induced a greater secondary antibody response than did an aqueous presentation when administered orally to guinea pigs which had been primed previously by subcutaneous injection. This result indicates that an effective hyposensitisation regimen could consist of a short series of initial parenteral injections, followed by an oral course of the protected allergen.
Authors:
A W Wheeler; D C Henderson; L J Youlten; I I Al-Janabi; B E Hickman; I H Taylor; D M Moran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  83     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-15     Completed Date:  1987-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylic Resins / pharmacology
Administration, Oral
Adult
Animals
Antibody Formation / drug effects
Desensitization, Immunologic / methods*
Drug Stability
Gastric Acid / physiology
Guinea Pigs
Humans
Immune Tolerance / drug effects*
Injections, Subcutaneous
Isoelectric Focusing
Pollen / analysis,  immunology*
Polymethacrylic Acids*
Radioallergosorbent Test
Tablets, Enteric-Coated* / analysis
Temperature
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Polymethacrylic Acids; 0/Tablets, Enteric-Coated; 25086-15-1/methylmethacrylate-methacrylic acid copolymer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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