| Immunogenicity of human B cell antigens solubilized from cultured human lymphoid cells. | |
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MedLine Citation:
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PMID: 139444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antigens solubilized from culured human lymphoid cells WI-L2 and RPMI 1788 were partially purified by ultracentrifugation on a KBr gradient. These antigens injected into rabbits produced xenoantibodies which after absorption with melanoma cells became specific to B cell antigens. Three such xenoantisera were submitted to the Second Histocompatibility Workshop of the Americas and reacted much like alloantisera to B cell antigens against a large panel of B peripheral lymphocytes and cells from patients with chronic lymphocytic leukemia. Xenoantisera to B cell antigens inhibited the mixed lymphocyte reaction, but did not affect the mitogenic activity of phytohemagglutinin or the functional properties of C3 receptors, monkey red blood cell receptors, or T cell receptors. |
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Authors:
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S Ferrone; M A Pellegrino; R A Reisfeld |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 118 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1977 Mar |
Date Detail:
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Created Date: 1977-05-20 Completed Date: 1977-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1036-41 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies Antibody Formation* Antigens B-Lymphocytes / immunology* Cell Line Cytotoxicity Tests, Immunologic HLA Antigens Humans Lymphocyte Activation Lymphocyte Culture Test, Mixed Ultracentrifugation |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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