Document Detail

Immunogenicity of hepatitis B vaccine in preterm and full term infants vaccinated within the first week of life.
MedLine Citation:
PMID:  11858862     Owner:  NLM     Status:  MEDLINE    
The immunogenicity of a Hepatitis B vaccine was evaluated in 110 neonates (57 full term and 53 preterm) born to Hepatitis B surface antigen (HBsAg) negative mothers. Three 10 microg doses of recombinant Hepatitis B vaccine were administered: the first dose within the first week of life; the second between 1 and 2 months; and the third at 5-7 months of age. Anti-HBs antibody titres were measured 3 months after the third dose. The seroconversion rate in preterm infants (77%; 95% CI=64.7-87.1) was significantly lower than in full term infants (98%; 95% CI=91.6-99.9) while the mean anti-HBs titres among those infants that did seroconvert was lower in preterm (186.6 mIU ml(-1)) than in full term infants (537.5 mIU ml(-1)). More full term than preterm infants showed titres greater than 100 mIU ml(-1) (71.9 and 41.5%, respectively). We conclude that the administration of a recombinant Hepatitis B vaccine shortly after birth is less immunogenic in preterm infants weighing <1800 g at birth than in full term infants. Currently accepted recommendations for post exposure perinatal prophylaxis may be inadequate to protect preterm infants.
Márcia Soares Freitas da Motta; Marisa Márcia Mussi-Pinhata; Salim Moysés Jorge; Clara Fumiko Tachibana Yoshida; Cleonice Barbosa Sandoval de Souza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vaccine     Volume:  20     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-22     Completed Date:  2002-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  England    
Other Details:
Languages:  eng     Pagination:  1557-62     Citation Subset:  IM    
Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Av. dos Bandeirantes no. 3900, Ribeirão Preto, São Paulo, Brazil.
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MeSH Terms
Hepatitis B / immunology,  prevention & control*,  transmission
Hepatitis B Antibodies / blood
Hepatitis B Surface Antigens / blood
Hepatitis B Vaccines / administration & dosage*,  immunology
Immunization Schedule
Infant, Newborn / immunology*
Infant, Premature / immunology*
Infectious Disease Transmission, Vertical
Vaccines, Synthetic / administration & dosage*,  immunology
Reg. No./Substance:
0/Engerix-B; 0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines; 0/Vaccines, Synthetic

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