| Immunogenicity of hepatitis B vaccine in preterm and full term infants vaccinated within the first week of life. | |
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MedLine Citation:
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PMID: 11858862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunogenicity of a Hepatitis B vaccine was evaluated in 110 neonates (57 full term and 53 preterm) born to Hepatitis B surface antigen (HBsAg) negative mothers. Three 10 microg doses of recombinant Hepatitis B vaccine were administered: the first dose within the first week of life; the second between 1 and 2 months; and the third at 5-7 months of age. Anti-HBs antibody titres were measured 3 months after the third dose. The seroconversion rate in preterm infants (77%; 95% CI=64.7-87.1) was significantly lower than in full term infants (98%; 95% CI=91.6-99.9) while the mean anti-HBs titres among those infants that did seroconvert was lower in preterm (186.6 mIU ml(-1)) than in full term infants (537.5 mIU ml(-1)). More full term than preterm infants showed titres greater than 100 mIU ml(-1) (71.9 and 41.5%, respectively). We conclude that the administration of a recombinant Hepatitis B vaccine shortly after birth is less immunogenic in preterm infants weighing <1800 g at birth than in full term infants. Currently accepted recommendations for post exposure perinatal prophylaxis may be inadequate to protect preterm infants. |
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Authors:
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Márcia Soares Freitas da Motta; Marisa Márcia Mussi-Pinhata; Salim Moysés Jorge; Clara Fumiko Tachibana Yoshida; Cleonice Barbosa Sandoval de Souza |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vaccine Volume: 20 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-22 Completed Date: 2002-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: England |
Other Details:
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Languages: eng Pagination: 1557-62 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Av. dos Bandeirantes no. 3900, Ribeirão Preto, São Paulo, Brazil. marciasfmotta@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hepatitis B / immunology, prevention & control*, transmission Hepatitis B Antibodies / blood Hepatitis B Surface Antigens / blood Hepatitis B Vaccines / administration & dosage*, immunology Humans Immunization Schedule Infant Infant, Newborn / immunology* Infant, Premature / immunology* Infectious Disease Transmission, Vertical Male Vaccines, Synthetic / administration & dosage*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Engerix-B; 0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines; 0/Vaccines, Synthetic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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