Document Detail

Immunogenicity of boiled compared with formalized leptospiral vaccines in rabbits, hamsters and humans.
MedLine Citation:
PMID:  7188698     Owner:  NLM     Status:  MEDLINE    
Leptospires (Leptospira interrogans serovar pomona) grown in chemically defined medium were immunogenic when given intradermally in humans if the leptospires were killed with formalin but not if they were boiled. Boiled leptospires were immunogenic for rabbits and hamsters and protected hamsters from challenge infection. On the other hand, boiled leptospires of the biflexa complex, serovar patoc, did retain some immunogenicity in humans, but the antisera did not protect hamsters against challenge with serovar pomona.
B Adler; S Faine
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of hygiene     Volume:  84     ISSN:  0022-1724     ISO Abbreviation:  J Hyg (Lond)     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0375374     Medline TA:  J Hyg (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
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MeSH Terms
Agglutination Tests
Antibodies, Bacterial / analysis
Antibody Formation*
Bacterial Vaccines / administration & dosage,  immunology*
Cross Reactions
Formaldehyde / pharmacology*
Guinea Pigs
Hemagglutination Tests
Hot Temperature*
Injections, Intradermal
Leptospira interrogans / drug effects,  immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 50-00-0/Formaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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