Document Detail


Immunogenicity of trivalent influenza vaccine in extremely low-birth-weight, premature versus term infants.
MedLine Citation:
PMID:  21273938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Influenza vaccine immunogenicity in premature infants is incompletely characterized.
OBJECTIVE: To assess the immunogenicity of trivalent, inactivated influenza vaccine (TIV) in extremely low-birth-weight (≤ 1000 g birth weight) premature (<30 weeks gestation) infants. We hypothesized that geometric mean titers of influenza antibody would be lower in premature than in full-term (FT) (≥ 37 week) infants.
DESIGN/METHODS: In this prospective multicenter study, former premature and FT infants who were 6 to 17 months of age received 2 doses of TIV during the 2006-2007 or 2007-2008 influenza seasons. Sera were drawn before dose 1, and 4 to 6 weeks after dose 2. Antibody was measured by hemagglutination inhibition.
RESULTS: Over 2 years, 41 premature and 42 FT infants were enrolled; 36 and 33 of these infants, respectively, had postvaccination titers available. Premature infants weighed less (mean, 1.3-1.8 kg difference) at the time of immunization than FT infants. Prevaccination titers did not differ between groups. Premature infants had higher postvaccination antibody geometric mean titers than FT infants to H1 (2006-2007, 1:513 vs. 1:91, P = 0.03; 2007-2008, 1:363 vs. 1:189, P = 0.02) and B/Victoria (2006-2007, 1:51 vs. 1:10, P = 0.02). More premature than FT infants had antibody titers ≥ 1:32 to B/Victoria (85% vs. 60%, P = 0.04) in 2007-2008. Two (5%) premature and 8 (19%) FT infants had adverse events, primarily fever, within 72 hours after vaccination. No child had medically diagnosed influenza.
CONCLUSIONS: Former premature infants had antibody responses to 2 TIV doses higher than or equal to those of FT children. Two TIV doses are immunogenic and well tolerated in extremely low-birth-weight, premature infants 6 to 17 months old.
Authors:
Carl T D'Angio; Roy J Heyne; Shahnaz Duara; Lucy C Holmes; T Michael O'Shea; Hongyue Wang; Dongwen Wang; Pablo J Sánchez; Robert C Welliver; Rita M Ryan; Kenneth C Schnabel; Caroline B Hall;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  30     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-15     Completed Date:  2011-09-27     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  570-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. carl_dangio@urmc.rochester.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00455169
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / blood*
Female
Hemagglutination Inhibition Tests
Humans
Immunization, Secondary / methods
Infant
Infant, Low Birth Weight
Infant, Newborn
Influenza Vaccines / administration & dosage,  immunology*
Influenza, Human / immunology,  prevention & control*
Male
Premature Birth
Prospective Studies
Vaccination / methods
Vaccines, Inactivated / administration & dosage,  immunology
Grant Support
ID/Acronym/Agency:
UL1 RR 024160/RR/NCRR NIH HHS; UL1 RR024160/RR/NCRR NIH HHS; UL1 RR024160-01/RR/NCRR NIH HHS; UL1 RR024160-02/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Influenza Vaccines; 0/Vaccines, Inactivated
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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