| Immunogenicity of a 24-valent Klebsiella capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide conjugate vaccine administered to victims of acute trauma. | |
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MedLine Citation:
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PMID: 8816151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured the antibody response in 10 victims of acute blunt trauma and penetrating trauma who were immunized against Klebsiella pneumoniae and Pseudomonas species within 72 hours of injury. The two vaccines, which were previously shown to be safe and immunogenic in uninjured humans, were a 24-valent K. pneumoniae capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide-toxin A conjugate vaccine. The patients were between 18 and 44 years of age, had Injury Severity Scores that ranged between 9 and 34, and did not have chronic infections or malignancies. On days 14 and 28 after immunization, all patients had a response of greater than fourfold to at least six of the nine Pseudomonas vaccine antigens. Half of the patients responded to eight of the nine antigens. Nine patients responded to at least 18 of 24 Klebsiella antigens, and seven patients responded to 22 of the 24 antigens. No important side effects were attributed to the vaccines. The results of this preliminary study indicate that active immunization against potential pathogens is possible in victims of acute trauma. |
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Authors:
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W N Campbell; E Hendrix; S Cryz; A S Cross |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 23 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-27 Completed Date: 1996-12-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 179-81 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Maryland School of Medicine, Baltimore, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Bacterial / biosynthesis, blood Bacterial Toxins / adverse effects, immunology, pharmacology* Bacterial Vaccines / adverse effects, immunology, pharmacology* Female Humans Immunoglobulin G / biosynthesis, blood Klebsiella Infections / prevention & control Klebsiella pneumoniae / immunology* Male O Antigens / immunology Polysaccharides, Bacterial / immunology Pseudomonas / immunology* Pseudomonas Infections / prevention & control Pseudomonas Vaccines Safety Vaccination Vaccines, Conjugate / adverse effects, immunology, pharmacology Wounds and Injuries / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Bacterial Toxins; 0/Bacterial Vaccines; 0/Immunoglobulin G; 0/O Antigens; 0/Polysaccharides, Bacterial; 0/Pseudomonas Vaccines; 0/Pseudomonas aeruginosa O polysaccharide-toxin A conjugate vaccine; 0/Vaccines, Conjugate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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