Document Detail

Immunogenetics of invasive aspergillosis.
MedLine Citation:
PMID:  20840014     Owner:  NLM     Status:  MEDLINE    
Invasive aspergillosis is one of the most important infections in hematopoietic stem cell transplant recipients, with an incidence rate of 5-15% and an associated mortality of 30-60%. It remains unclear why certain patients develop invasive aspergillosis while others, undergoing identical transplant regimen and similar post transplant immunosuppression, do not. Over the last decade, pattern recognition receptors such as Toll-like receptors (TLRs) and the C-type lectin receptors (CLRs) have emerged as critical components of the innate immune system. By detecting specific molecular patterns from invading microbes and initiating inflammatory and subsequent adaptive immune responses, pattern recognition receptors are strategically located at the molecular interface of hosts and pathogens. Polymorphisms in pattern recognition receptors and downstream signaling molecules have been associated with increased or decreased susceptibility to infections, suggesting that their detection may have an increasing impact on the treatment and prevention of infectious diseases in the coming years. Infectious risk stratification may be particularly relevant for patients with hematologic malignancies, because of the high prevalence and severity of infections in this population. This review summarizes the innate immune mechanisms involved in Aspergillus fumigatus detection and the role of host genetic polymorphisms in susceptibility to invasive aspergillosis.
Frédéric Lamoth; Ivana Rubino; Pierre-Yves Bochud
Related Documents :
17496434 - Ppar ligands: are they potential agents for cardiovascular disorders?
16219804 - Cpg-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-4...
16442504 - Peroxisome-proliferator-activated receptor-gamma (ppargamma) activation protects neuron...
17060494 - Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer...
8083754 - Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion ne...
8469394 - Muscarinic receptor-mediated induction of fos protein in rat brain.
Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-15
Journal Detail:
Title:  Medical mycology     Volume:  49 Suppl 1     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2012-04-16     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S125-36     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspergillosis / genetics*,  immunology*
Aspergillus / immunology*,  pathogenicity
Hematopoietic Stem Cell Transplantation / adverse effects
Immunity, Innate
Immunosuppression / adverse effects
Lectins, C-Type / genetics,  immunology
Polymorphism, Genetic*
Receptors, Pattern Recognition / genetics*,  immunology
Risk Factors
Signal Transduction / immunology
Toll-Like Receptors / genetics,  immunology,  physiology
Reg. No./Substance:
0/Lectins, C-Type; 0/Receptors, Pattern Recognition; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  T3 regulates E-cadherin, and ?- and ?-catenin expression in the stomach during the metamorphosis of ...
Next Document:  Expression of ?-catenin in rheumatoid arthritis fibroblast-like synoviocytes.