Document Detail


Immunogenetics of HIV disease.
MedLine Citation:
PMID:  23772624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Host genetic factors are a major contributing factor to the inter-individual variation observed in response to human immunodeficiency virus (HIV) infection and are linked to resistance to HIV infection among exposed individuals, as well as rate of disease progression and the likelihood of viral transmission. Of the genetic variants that have been shown to affect the natural history of HIV infection, the human leukocyte antigen (HLA) class I genes exhibit the strongest and most consistent association, underscoring a central role for CD8(+) T cells in resistance to the virus. HLA proteins play important roles in T-cell-mediated adaptive immunity by presenting immunodominant HIV epitopes to cytotoxic T lymphocytes (CTLs) and CD4(+) T cells. Genetic and functional data also indicate a function for HLA in natural killer cell-mediated innate immunity against HIV by interacting with killer cell immunoglobulin-like receptors (KIR). We review the HLA and KIR associations with HIV disease and discuss the mechanisms underlying these associations.
Authors:
Maureen P Martin; Mary Carrington
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  254     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-01-24     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  245-64     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution
Gene Expression Regulation
Genetic Loci
Genetic Variation
Genome-Wide Association Study
HIV / physiology
HIV Infections / genetics*,  immunology*
HLA Antigens / genetics,  immunology
Heterozygote
Humans
Killer Cells, Natural / immunology
Potassium Channels, Inwardly Rectifying / genetics,  immunology
Grant Support
ID/Acronym/Agency:
HHSN261200800001E/CA/NCI NIH HHS; HHSN261200800001E//PHS HHS
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Potassium Channels, Inwardly Rectifying
Comments/Corrections

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