Document Detail

Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis.
MedLine Citation:
PMID:  1679476     Owner:  NLM     Status:  MEDLINE    
75 systemic sclerosis patients were independently tested for pulmonary fibrosis, autoantibodies, and MHC class II genes. 24 of 42 (57%) patients with pulmonary fibrosis had either HLA DR3/DRw52a or anti-Scl-70 vs 2 of 33 (6%) patients without pulmonary fibrosis. The presence of DR3/DRw52a or anti-Scl-70 gives a relative risk of 16.7 for the development of pulmonary fibrosis in a patient with scleroderma--a risk substantial enough to require careful monitoring of these patients and treatment at an early stage of disease.
D C Briggs; R W Vaughan; K I Welsh; A Myers; R M duBois; C M Black
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  338     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  661-2     Citation Subset:  AIM; IM    
Department of Immunogenetics, Guy's Hospital, London, UK.
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MeSH Terms
Autoantibodies / analysis
DNA / analysis
HLA-DR3 Antigen / genetics
HLA-DR5 Antigen / genetics
Haplotypes / genetics
Nuclear Proteins / immunology
Pulmonary Fibrosis / etiology*,  immunology
Scleroderma, Systemic / complications*,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/HLA-DR3 Antigen; 0/HLA-DR5 Antigen; 0/Nuclear Proteins; 0/Scl 70 antigen, human; 9007-49-2/DNA
Comment In:
Lancet. 1991 Nov 2;338(8775):1152   [PMID:  1682577 ]

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