Document Detail

Immunogenetic characteristics of patients with autoimmune gastritis.
MedLine Citation:
PMID:  20082482     Owner:  NLM     Status:  MEDLINE    
AIM: To explore whether predisposition to autoimmune gastritis (AIG) is found in human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like receptor (KIR) gene variations.
METHODS: Twelve Finnish patients with autoimmune-type severe atrophy of the gastric corpus were included. The patients' serum was analyzed for pepsinogen I and Helicobacter pylori (H. pylori) antibodies. DNA was separated and the patients were genotyped for HLA-A, B, Cw, DRB1 and DQB1 antigens, and studied for single nucleotide polymorphisms for the following cytokines: interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, IL-12, interferon gamma, transforming growth factor beta, and tumor necrosis factor alpha. Variation in KIR genes was also explored. The results were compared with prevalence of the polymorphisms in Finnish or European populations.
RESULTS: All patients had pepsinogen I levels below normal (mean: 11 microg/L, range: < 5 to 25 microg/L). Three patients had elevated H. pylori IgG antibodies, while H. pylori serology was negative in the rest of the patients. AIG patients carried significantly more often HLA-DRB1*04 (58%) and DQB1*03 (83%) than the general Finnish population did (28% and 51%, respectively; P = 0.045 and 0.034 by the Fisher's exact test). No patient was positive for HLA-B8-DRB1*03, a well-established autoimmune marker. Neither cytokine polymorphisms nor KIR gene variation showed association with AIG.
CONCLUSION: As explored with modern DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may predispose to AIG.
Aino Mirjam Oksanen; Katri Eerika Haimila; Hilpi Iris Kaarina Rautelin; Jukka Antero Partanen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-04-20     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
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MeSH Terms
Autoimmune Diseases / ethnology,  genetics*
Case-Control Studies
Cytokines / genetics
Czech Republic
Gastritis / ethnology,  genetics*
Genetic Predisposition to Disease / genetics*
HLA-DQ Antigens / genetics*
HLA-DQ beta-Chains
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Membrane Glycoproteins / genetics*
Middle Aged
Polymorphism, Single Nucleotide / genetics
Potassium Channels, Inwardly Rectifying / genetics
Reg. No./Substance:
0/Cytokines; 0/HLA-DQ Antigens; 0/HLA-DQ beta-Chains; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/HLA-DRB1 Chains; 0/HLA-DRB1*04 antigen; 0/Membrane Glycoproteins; 0/Potassium Channels, Inwardly Rectifying

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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