Document Detail


Immunogenetic aspects of erosive osteoarthritis of the hand in patients from northern Italy.
MedLine Citation:
PMID:  20919945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare the distribution of human leucocyte antigen (HLA) class I and II alleles in patients with erosive hand osteoarthritis (EHOA) to that of patients with non-erosive hand OA (non-EHOA) and in healthy Italian Bone Marrow Donors (IBMDs), in order to evaluate possible immunogenetic associations with EHOA. In the EHOA group we also sought possible associations between HLA alleles and disease severity.
METHODS: Ninety-four patients with EHOA (82 women, 12 men; mean age 61.4 ± 8.45 years) and 37 with non-EHOA (28 women, nine men; mean age 59.21 ± 9.07 years) were studied. Disease severity was measured by the number of clinically active joints (NCAJ) and by the radiographic score (RS) using the Kallman scale. HLA typing was undertaken for A, B, C, and DRB1 loci; HLA-DRB1* genotyping was determined using polymerase chain reaction (PCR) with sequence-specific primers. Frequencies were compared with those of the healthy IBMDs.
RESULTS: The alleles found more frequently in EHOA patients than in non-EHOA patients and healthy controls were: A23, A26, and A29; B38, B44, and HLA DRB1*01 and *07. The RS was more severe in the EHOA compared to the non-EHOA group (63.60 ± 23.14 vs. 34.34 ± 20.24, p < 0.001). Within the EHOA group, HLA-DRB1*07 was associated with a higher RS (67.36 ± 23 vs. 64.5 ± 18.5, p = 0.029).
CONCLUSION: In this study of North Italian patients affected with EHOA, the HLA-DRB1*07 allele was found to be associated with both the development and greater severity of the disease.
Authors:
R Ramonda; E Musacchio; C Campana; M Frigato; P Frallonardo; V Barbieri; A Piccoli; C Valvason; V Bronte; P Zanovello; L Punzi
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Publication Detail:
Type:  Journal Article     Date:  2010-10-05
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  40     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-05-19     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Female
Gene Frequency / genetics
HLA-DR Antigens / genetics
HLA-DRB1 Chains
Hand Joints / physiopathology*
Histocompatibility Antigens Class I / genetics
Histocompatibility Antigens Class II / genetics
Humans
Immunogenetic Phenomena / genetics*,  physiology*
Italy
Male
Middle Aged
Osteoarthritis / ethnology*,  genetics*,  physiopathology
Severity of Illness Index
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/HLA-DRB1 Chains; 0/HLA-DRB1*07 antigen; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II

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